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目的探讨泻肝凉血解毒方治疗银屑病的作用机制。方法将豚鼠随机分为空白组、模型组、泻肝凉血解毒方组和阿维A胶囊组。采用普萘洛尔乳剂外涂豚鼠耳背皮肤复制银屑病模型。各组给予相应处理,疗程4周。观察豚鼠一般情况、局部皮损病理变化、皮损组织和血清肿瘤坏死因子(TNF-α)表达变化。结果 1模型组豚鼠耳部皮肤呈典型的银屑病样病理改变,泻肝凉血解毒方组和阿维A胶囊组皮损组织病理明显改善;2与空白组比较,模型组皮损组织和血清TNF-α水平升高(P<0.05);与模型组比较,泻肝凉血解毒方组和阿维A胶囊组皮损组织和血清TNF-α水平降低(P<0.05);但两治疗组之间TNF-α水平无显著性差异(P>0.05)。结论泻肝凉血解毒方治疗银屑病的机制可能与降低局部组织和血清TNF-α水平有关。
Objective To explore the mechanism of Xiegan Liangxue Jiedu Fang in treating psoriasis. Methods Guinea pigs were randomly divided into blank group, model group, Xieganliangxue Jiedu Fang group and Avia A capsule group. Propranolol emulsion was used to coat the guinea pig dorsal skin to replicate the psoriasis model. Each group given the appropriate treatment, treatment for 4 weeks. The general situation of guinea pigs was observed. The pathological changes of the local lesion, the changes of tumor necrosis factor (TNF-α) and the tissue of the lesion were observed. Results 1 The model group had typical psoriasis-like pathological changes in the ear skin of the model group. The pathological changes of the skin lesions in Xiegan Liangxue Jiedu Fang group and Avia A capsule group were significantly improved. 2 Compared with the blank group, (P <0.05). Compared with the model group, the levels of TNF-α in the lesion tissues and serum in Xiegan Liangxue Jiedu Fang group and Yawei A capsule group were lower (P <0.05) There was no significant difference in TNF-α levels between groups (P> 0.05). Conclusion Xie Gan Liang Xue Jie Du Fang treatment of psoriasis mechanism may be related to the reduction of local tissue and serum TNF-α levels.