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目的:有机酸是由于氨基酸、脂肪、糖代谢异常导致的中间产物,体内有机酸增多会引起一系列病理生理改变和临床上的一系列疾病。尤其是儿童,有机酸代谢性疾病虽然比较少见,但其致死率和致残率很高,通过分析我院5例病例,阐明影像学检查对此疾病的早期诊断及预后评估的重要作用。方法:对我院2005年至2010年经临床确诊的五例儿童有机酸症患者的CT及MRI等影像资料的分析及回顾,研究此疾病的早期影像学表现。结果:五例患者中可以为临床提供有明显价值影像资料的三例,可以提供有参考价值及临床治疗导向的二例。结论:儿童有机酸症的早期诊断,影像学检查可以提供有价值诊断,对此疾病的早期诊断有很重要的意义。
OBJECTIVE: Organic acids are intermediate products due to abnormal amino acids, lipids and glucose metabolism. The increase of organic acids in the body causes a series of pathophysiological changes and a series of clinical diseases. Especially children, organic acid metabolic diseases are relatively rare, but their fatality and morbidity are high. By analyzing 5 cases in our hospital, we clarify the important role of imaging examination in the early diagnosis and prognosis evaluation of this disease. Methods: From 2005 to 2010 in our hospital clinically diagnosed five cases of organic acidosis in children with CT and MRI image data analysis and review of the disease early imaging findings. Results: Of the five patients, three patients with clinically significant imaging data could be provided. Two cases could be provided with reference value and clinical treatment orientation. Conclusion: Early diagnosis of organic acidosis in children, imaging examination can provide valuable diagnosis, the early diagnosis of the disease is of great significance.