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目的 :探讨氯硝西泮对持续性TD的临床作用。方法 :对 12例精神分裂症持续性TD患者加用小剂量氯硝西泮 ,用AIMS、TDRS、TESS和BPRS ,随访半年 ,进行前瞻性开放性研究。结果 :加服氯硝西泮前后自身对照比较 :AIMS严重度分除加药第 2周和第 12周外 ,差异均有显著性 (P <0 .0 5 ) ,4例患者 ( 3 3 .3 % )加氯硝西泮后不自主运动明显改善 ,未见反复。结论 :小剂量氯硝西泮治疗部分持续性TD患者有一定疗效 ,安全性较好
Objective: To investigate the clinical effect of clonazepam on persistent TD. METHODS: Twelve patients with persistent TD with schizophrenia were treated with low-dose clonazepam and followed up for six months with AIMS, TDRS, TESS, and BPRS for a prospective open-label study. Results: Before and after clonazepam plus self-control comparison: AIMS severity score addition at the second week and the twelfth week, the differences were significant (P <0.05), 4 patients (33). 3%) plus clonazepam after involuntary movement improved significantly, no repeated. Conclusion: The low-dose clonazepam has some curative effect and good safety in the treatment of some patients with persistent TD