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目的 应用克乳痛中药复方制剂 ,对大鼠实验性乳腺增生病的治疗作用进行研究。方法 用苯甲酸雌二醇复制乳腺增生病大鼠模型。制模中和制模后 ,分别用不同剂量克乳痛对照观察乳腺的组织学形态 ,乳腺上皮细胞的雌激素受体 (ER) ,孕激素受体 (PR)变化 ,并做核仁组成区相关嗜银蛋白 (AgNOR)染色及电镜观察。 结果 中药克乳痛能抑制乳腺上皮增殖并通过降低大鼠乳腺组织ER、PR的含量。结论 中药克乳痛对实验性乳腺增生病有调节、治疗作用。
OBJECTIVE: To investigate the therapeutic effects of experimental Chinese medicine for hyperplasia of mammary glands using Ketongtongtong traditional Chinese medicine compound preparation. Methods Estradiol benzoate was used to replicate the rat model of mammary gland hyperplasia. After molding and after molding, the histological morphology of the mammary glands, changes in estrogen receptor (ER) and progesterone receptor (PR) of mammary epithelial cells were observed with different doses of glucocalatoin control, and the nucleolar component area was made. AgNOR staining and electron microscopy. RESULTS: Chinese herbal medicine milk-induced pain can inhibit the proliferation of breast epithelium and reduce the content of ER and PR in mammary glands of rats. Conclusion Chinese herbal medicine milk pain can regulate and treat experimental hyperplasia of mammary glands.