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目的:探讨托吡酯(妥泰)添加及单一治疗小儿部分性发作癫(?)的疗效及不良反应。方法:对确诊为部分性发作癫(?)的１９例患儿添加妥泰,１３例单一治疗,均进行自身对照的开放性研究。妥泰剂量由１ｍｇ·ｋｇ－１·ｄ－１开始,分每日２次,每周增加１ｍｇ·ｋｇ－１·ｄ－１,直至出现疗效或不能再耐受的不良反应。结果:对上述病例妥泰治疗平均疗程(５．３±１．９)个月;３２例中总的有效率占８１．３%,完全控制４６．９%。不良反应轻。结论:妥泰对部分性发作癫(?)单一和添加治疗,是一安全而有效的抗癫(?)药物。
Objective: To investigate the efficacy and side effects of topiramate (Topiramate) and monotherapy in the treatment of pediatric partial seizure epilepsy (?). METHODS: Nineteen children diagnosed with partial onset epilepsy (?) Were enrolled in topiramate and 13 single treatments, both of whom underwent an open-label study of their own control. Topotecan dose from 1mg · kg-1 · d-1, divided into 2 times a day, weekly increase of 1mg · kg-1 · d-1, until the efficacy or can no longer tolerate the adverse reactions. Results: The average duration of topiramate treatment was 5.3 ± 1.9 months. The total effective rate was 81.3% in 32 cases and 46.9% in complete control. Adverse reactions are mild. Conclusion: Topiramate is a safe and effective antiepileptic agent for partial and epileptic (?) Monotherapy.