多发性骨髓瘤是浆细胞异常增生的恶性肿瘤,异常浆细胞浸润骨骼和软组织,其次骨髓瘤代谢异常引起机体一系列代谢异常,产生M球蛋白及过量轻链引起骨骼破坏、贫血,免疫球蛋白异常及肾脏损害。此病虽是一种少见病,但非为罕见病,目前有增加趋势。多发性骨髓瘤肾脏损害的诊断依据:1.骨骼X线典型表现;2.骨髓细胞形态学检查,异常浆细胞>10～20%;3.血浆蛋白电泳出现M蛋白带,免疫球蛋白异常增高及本周恩蛋白阳性;4.间歇或持续尿蛋白或RBC>5/HP管型阳性或肾功能损害;5.除外其他原因肾 Multiple myeloma is a malignant tumor of abnormal proliferation of plasma cells, abnormal plasma cells infiltrating bone and soft tissue, followed by abnormal metabolism of myeloma caused a series of metabolic disorders, resulting in M ​​globulin and excessive light chain damage caused by bone, anemia, immunoglobulin Abnormal and kidney damage. Although the disease is a rare disease, but not a rare disease, there is an increasing trend. The diagnosis of multiple myeloma kidney damage based on: 1. X-ray bone typical performance; 2. Bone marrow cell morphology examination, abnormal plasma cells> 10 to 20%; 3. Plasma protein electrophoresis appeared M protein band, abnormal immunoglobulin increased And enamel positive this week; 4. Intermittent or continuous urinary protein or RBC> 5 / HP tubular positive or renal dysfunction; 5. Except for other causes kidney