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目的：探讨小剂量美托洛尔（ｍｅｔｏｐｒｏｌｏｌ）防治大鼠急性心肌梗死（ＡＭＩ）左心室重构（ＬＶＲＭ）的作用。 方法：７０只雌性ＡＭＩ大鼠随机分成ＡＭＩ对照组（ｎ＝３５）和小剂量美托洛尔［２ｍｇ/kg·ｄ）]组（ｎ＝３５）。另设假手术组（ｎ＝１６）做对照。给药４周后行血流动力学测定和病理分析。 结果：ＡＭＩ对照组与假手术组相比，左心室舒张末压、容积、重量以及室间隔厚度均增加，有极显著性差异（P均＜０.００１＝，左心室内压最大上升和下降速率（±ｄｐ／ｄｔｍａｘ）及其左心室收缩压的校正值（±ｄｐ／ｄｔ／ＬＶＳＰ）均显著降低，有极显著性差异（P均＜０.００１＝。小剂量美托洛尔组与ＡＭＩ对照组相比，左心室舒张末压和容积均显著降低，有极显著性差异（P＜０.０１～０.００１＝，球形指数和±ｄｐ／ｄｔｍａｘ及±ｄｐ／ｄｔ／ＬＶＳＰ均显著增加，有极显著性差异（P＜０.０５～０.００１＝，而室间隔厚度和左心室重量均无显著差异（P均＞０.０５）。 结论：小剂量美托洛尔能有效防治大鼠ＡＭＩ左心室扩张，改善血流动力学和左心室功能，但似不能抑制左心室肥厚。
Objective: To investigate the effect of metoprolol in preventing and treating left ventricular remodeling (LVRM) in rats with acute myocardial infarction (AMI). Methods: Seventy female AMI rats were randomly divided into AMI control group (n = 35) and low dose metoprolol [2 mg / kg · d] group (n = 35). Another sham operation group (n = 16) as a control. Four weeks after the administration, hemodynamic determination and pathological analysis were performed. Results: Compared with the sham operation group, the left ventricular end-diastolic pressure, volume, weight and ventricular septum thickness increased in AMI control group (P <0.001, maximal increase of left ventricular pressure and The decrease rate (± dp / dtmax) and the corrected value of left ventricular systolic pressure (± dp / dt / LVSP) were significantly lower (P <0.001 = Compared with AMI group, left ventricular end-diastolic pressure and volume were significantly decreased (P <0. 01 ~ 0.001 =, spherical index and ± dp / dtmax and ± dp / dt / LVSP were significantly increased (P <0. 05 ~ 0.001 =, while the thickness of ventricular septum and left ventricular weight were not significantly different (P all> 0. 05) .Conclusion: Small doses Metoprolol can effectively prevent left ventricular dilatation of AMI, improve hemodynamics and left ventricular function, but it can not inhibit left ventricular hypertrophy.