早在上世纪50年代,人们就发现通过抑制细菌核酸合成可以达到抑制细菌生长的作用,并相继有许多抗菌素的问世。此后,又发现核酸合成抑制剂具有较强的抗病毒作用。20世纪80年代以来,核苷衍生物作为嘌呤核苷和嘧啶核苷在核酸合成过程中的抑制剂,已经逐步成为抗病毒药物的研究热点,特 As early as the 1950s, people found that by inhibiting bacterial nucleic acid synthesis can inhibit the growth of bacteria, and have come out with many antibiotics. Since then, nucleic acid synthesis inhibitors have also been found to have a stronger antiviral effect. Since the 1980s, nucleoside derivatives as inhibitors of purine nucleosides and pyrimidine nucleosides in the process of nucleic acid synthesis have gradually become hot topics of antiviral drugs, especially