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目的探讨舟山海岛HBV慢性感染者中乙肝前S1抗原与表面抗原(HBsAg)滴度的关系。方法收集152例舟山海岛慢性乙型肝炎(CHB)患者血清,用ELISA法分别检测乙肝前S1抗原和表面抗原滴度。结果乙肝前S1抗原阳性102例,其中乙肝表面抗原滴度≥1∶500的87例(85.29%);乙肝前S1抗原阴性50例,其中表面抗原滴度≥1∶500的2例(4.00%)。两组比较,χ2=91.37,P<0.01;乙肝前S1抗原阳性组表面抗原平均滴度为1∶707.95,阴性组平均滴度为1∶51.52(t=17.00,P<0.01)。结论舟山海岛CHB患者血清中乙肝前S1抗原与表面抗原滴度呈正相关,是诊断慢性乙肝病毒血症的可靠指标。
Objective To investigate the relationship between hepatitis B preS1 antigen and surface antigen (HBsAg) titer in chronic hepatitis B virus infected patients in Zhoushan island. Methods A total of 152 patients with chronic hepatitis B (CHB) from Zhoushan Island were enrolled in this study. The titer of pre-S1 antigen and surface antigen of hepatitis B were detected by ELISA. Results There were 102 positive cases of hepatitis B pre-S1 antigen (85.29%) with hepatitis B surface antigen titer≥1: 500; 50 cases were negative of hepatitis B pre-S1 antigen, 2 cases (4.00% ). The mean titers of surface antigens in pre-S1 antigen positive group were 1: 707.95, while those in negative group were 1:51.52 (t = 17.00, P <0.01). Conclusion Serum HBsAg in patients with CHB in Zhoushan island is positively correlated with the titer of HBsAg, which is a reliable indicator for the diagnosis of chronic hepatitis B viremia.