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目的研究肠易激综合征(IBS)患者胆囊(GB)排空不良的发生机制,探讨硝苯吡啶对GB排空不良的治疗作用.方法按随机双盲和对照的方法,应用实时超声研究不同亚型IBS患者37例和正常对照组26例(两组性别、年龄、身高、体重等均相匹配)的GB排空功能.结果IBS患者餐后60minGB排出量(GEF,x±s,%,651±21)明显少于对照组(802±15,P<001).对照组口服硝苯吡啶10mg后70min,GEF显著减少(802±15~682±20,P<001),20mg(606±19)较10mg者更著;GB排空时间明显延长(604min±11min~785min±13min,P<001).IBS患者口服硝苯吡啶10mg后25minGEF(254±16~297±16,P<001)即明显增加,20mg者(254±16~331±18,P<001)尤著,70min达最大;GB排空速度明显加快,平均最大GEF时间(服药前、服硝苯吡啶10mg和20mg后分别为836,762和691min)明显缩短(P<001).餐后45min节段收缩型(485±22)和其他?
Objective To study the mechanism of poor emptying of gallbladder (GB) in patients with irritable bowel syndrome (IBS) and to explore the therapeutic effect of nifedipine on poor emptying of GB. Methods According to the randomized, double-blind and control methods, real-time ultrasound was used to study the GB-emptying function in 37 patients with different subtypes of IBS and 26 healthy controls (gender, age, height, weight, etc.). Results The discharge of 60 min after meal (GEF, x ± s,%, 651 ± 21) in patients with IBS was significantly less than that in the control group (802 ± 15, P <001). The control group received nifedipine 10mg 70min, GEF was significantly reduced (80 2 1 5 ~ 68 2 ± 2 0, P <0 01), 20 mg (60 6 ± 1 9) than 10 mg More; GB evacuation time was significantly prolonged (60 4min ± 1 1min ~ 78 5min ± 1 3min, P <0 01). IBS patients after oral nifedipine 10mg 25minGEF (254 ± 16 ~ 297 ± 16, P <001) that is significantly increased, 20mg (254 ± 1 6 ~ 33 1 ± 18, P <001), reaching the maximum at 70 min; the evacuation rate of GB significantly accelerated and the mean maximum GEF time (pretreatment, nifedipine 10 mg and 20 mg respectively, 836,762 And 691min) were significantly shorter (P <001). 45min after the segment segmental contraction (48 5 ± 2 2) and other?