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目的:研究红黑二丸提取物对凝血系统的作用,了解其促凝血效应。方法:取小鼠和大鼠随机均分为对照组和红黑二丸组,红黑二丸组灌胃给于红黑二丸提取物l ml/100 g bw,对照组灌胃给于等体积生理盐水,qd,连续给药7 d后,分别测定小鼠出血时间(BT)、血凝血时间(CT)、大鼠的活化部分凝血活酶时间(APTT)和凝血酶原时间(PT)、全血浆凝块溶解时间及血小板数(PLT)。结果:与对照组相比,红黑二丸提取物能明显缩短BT,降低CT、APTT和PT。同时,红黑二丸提取物能使全血浆凝块溶解时间延长、血小板数增高。结论:红黑二丸具有明显的促凝血作用。
Objective: To study the effect of Honghe Erhuan Pill on coagulation system and its procoagulant effect. Methods: The mice and rats were randomly divided into the control group and the Honghediwan group. The Honghediwan group was given gavage with the extract of Honghe Erh Wan lml / 100g bw, while the control group was given gavage Volume of normal saline, qd, after continuous administration for 7 days, the bleeding time (BT), the clotting time (CT), the APTT and the PT of the mice were measured respectively. , Total plasma clot lysis time and platelet count (PLT). Results: Compared with the control group, Honghe Erwan extract can significantly shorten the BT, reduce CT, APTT and PT. At the same time, red and black two pill extract can make the whole plasma clot lysis time, increased platelet count. Conclusion: Honghe pill has obvious procoagulant effect.