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目的探讨牛痘疫苗致炎兔皮提取物注射液缓解带状疱疹后遗神经痛(PHN)的临床疗效。方法将119例PHN患者随机分为观察组和对照组。观察组肌肉注射牛痘疫苗致炎兔皮提取物注射液3 ml,一日1次注射;对照组口服甲钻胺片,一日3次,每次一片0.5 mg;疗程均为2周。治疗前及治疗第3、7、14天分别采用目测类比评分法(VAS)评定疼痛程度并评价有效率,同时观察治疗过程中的不良反应。结果观察组治疗VAS评分在治疗第3天开始下降,与治疗前和对照组比较,差异具有统计学意义(P<0.05),治疗第7和14天VAS评分下降更为显著(P<0.01)。2周治疗结束后,观察组与对照组有效率分别为90.9%和20.3%,组间差异具有统计学意义(P<0.01)。观察组出现注射部位轻微疼痛1例,不良反应发生率为1.8%。结论牛痘疫苗致炎兔皮提取物注射液用于治疗PHN疼痛,临床疗效显著,起效快,无明显不良反应。
Objective To investigate the clinical efficacy of injecting vaccinia vaccination rabbits skin extract in relieving herpes zoster neuralgia (PHN). Methods 119 cases of PHN were randomly divided into observation group and control group. Observation group intramuscular injection of vaccinia vaccine Rabbit skin extract injection 3 ml, 1 injection on the 1st; control group oral methylprednisolone tablets, 3 times a day, each 0.5 mg; course of treatment were 2 weeks. Before treatment and on the 3rd, 7th and 14th days of treatment, visual analogue scale (VAS) was used to assess the pain degree and evaluate the effective rate, and to observe the adverse reactions during the treatment. Results The VAS score of the observation group began to decline on the third day of treatment, with a significant difference (P <0.05) compared with that before treatment and the control group. The VAS score decreased more significantly on the seventh and the 14th day after treatment (P <0.01) . After two weeks of treatment, the effective rates of the observation group and the control group were 90.9% and 20.3%, respectively. The differences between the two groups were statistically significant (P <0.01). In the observation group, 1 patient had slight pain at the injection site, and the incidence of adverse reactions was 1.8%. Conclusion The vaccination of vaccinia vaccination rabbit skin extract for the treatment of PHN pain, clinical significant effect, rapid onset, no significant adverse reactions.