目的：对不同浓度蜂蜡为阻滞剂，制备的布洛芬控释人工骨（ＩＢＦＰＨＡＷＡＸ） 进行体外释药实验，考察ＩＢＦＰＨＡＷＡＸ中布洛芬的释放规律。方法：用紫外分光光度法于２２１ ｎｍ 处测定包裹与未包裹蜂蜡的ＩＢＦＰＨＡＷＡＸ每天的释药量。结果：药物溶出５０ ％ 时，未包裹蜂蜡、包裹２０ ％ 蜂蜡和包裹３０％ 蜂蜡的ＩＢＦＰＨＡＷＡＸ，体外释药时间分别为６ ｄ，１２ ｄ 和１７ ｄ，蜂蜡浓度越高，药物释放就越慢。结论：ＩＢＦＰＨＡＷＡＸ可有效控制药物的释放，本药物缓释系统实现了以不同蜂蜡浓度调节药物释放速度。 OBJECTIVE: To study the in vitro release of ibuprofen controlled release artificial bone (IBFPHAWAX) with different concentrations of beeswax as blocker, and investigate the release of ibuprofen in IBFPHAWAX. Methods: UV spectrophotometry at 221 nm at the wrapped and unwrapped beeswax IBF PHA WAX daily release. Results: IBFPHAWAX without beeswax, 20% beeswax and 30% beeswax were dissolved in the drug for 6 days, and the release time was 6 d, 12 d and 17 d, respectively. The higher the concentration of beeswax, The slower. Conclusion: IBF PHA WAX can effectively control the release of drugs, the drug delivery system to achieve a different concentration of beeswax regulation of drug release rate.