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BJUInt,2006,98(2):414-423.为观察磷酸二酯酶-5(PDE5)、cGMP和cGMP依赖性蛋白激酶I(PKG1)在母猪和人类尿道中的分布,并评价PDE5抑制剂对于离体猪和人类尿道的药理学作用(NO/cGMP通路产生的抑制信号可以降低膀胱排空时膀胱出口和尿道的压力)。Werkstr m等进行了一项研究。在获
BJUInt, 2006, 98 (2): 414-423. To investigate the distribution of phosphodiesterase-5 (PDE5), cGMP and cGMP-dependent protein kinase I (PKG1) in sows and human urethra and to evaluate PDE5 inhibition The pharmacological effect of the agent on ex vivo pigs and human urethra (the inhibitory signal produced by the NO / cGMP pathway can reduce bladder outlet and urethral pressure upon bladder emptying). Werkstr m and other conducted a study. In the get