Rhazinal是Rhazinilam家族中的一员,其家族都含有一个因环张力而形成的吡咯-苯胺手性轴,一个高张力的九元内酰胺,一个全碳季碳手性中心以及[3.4]并环结构.Rhazinilam被发现是一个很好的多种癌细胞的抑制剂,具有诱导和促进微管蛋白的聚合、防止解聚、稳定微管的作用.自其被分离之后得到了有机和生物有机化学家的广泛重视,至今已有多个其家族成员的全合成的报道.中国科学技术大学化学系顾振华小组将Pd催化的Catellani反应首次成 Rhazinal is a member of the Rhazinilam family whose family contains a pyrrole-aniline chiral axis due to ring tension, a high-tension nine-membered lactam, an all-carbon quaternary chiral center and [3.4] Structure .Rhazinilam was found to be a good inhibitor of a variety of cancer cells with the ability to induce and promote the polymerization of tubulin and prevent depolymerization and stabilize microtubules. Since its isolation, organic and bioorganic chemistry Home widespread attention, so far there have been more than one family members of the full synthesis of reports.University of Science and Technology of China Gu Zhenhua Group Pd-catalyzed Catellani reaction for the first time into