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目前已从两栖类皮肤中至少提取出了十九种生物活性肽,在这方面Erspamer及其同工(1980)进行了大量的工作;另外与其结构相似的物质在鸟类和哺乳类的脑和肠道中发现。对其中了解最多的首先是从一种欧洲铃蟾(Bombina bombina)皮肤中获得的十四肽——蛙皮素(Bombesin),其结构已被合成成功而证实。从另一种蛙(Alytes obstetricans)皮肤中提取出的与Bombesin在结构上极为相似的Alytesin,则对哺乳类平滑肌、血压、泌尿以及胃酸分泌具有相反的作用。相继从蛙或蟾蜍提取的肽类在结构上有相似点,例如所有这些
At present, at least nineteen bioactive peptides have been extracted from amphibian skin. Erspamer and his colleagues (1980) have done a great deal of work in this area; in addition, structurally similar substances have been studied in birds and mammalian brains and Found in the intestine. The first of these is the fourteen peptide, Bombesin, obtained from the skin of a Bombina bombina whose structure has been confirmed to be successful. Alytesin, which is structurally similar to Bombesin extracted from the skin of another Alytes obstetricans, has the opposite effect on mammalian smooth muscle, blood pressure, urinary and gastric acid secretion. Peptides that have been extracted one after another from frogs or toads have similar structures, for example all of them