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作者对从与疫苗有关病例分离的Ⅱ和Ⅲ型脊髓灰质炎病毒各11株,用病毒基因组寡核苷酸图谱和病毒蛋白 PAGE 进行分析,发现疫苗病毒通过人体复制能发生多种遗传改变。
The authors analyzed 11 strains of type II and III poliovirus isolated from vaccine related cases using viral genome oligonucleotide maps and viral protein PAGE and found that the vaccine virus can undergo multiple genetic changes through human replication.