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微小核糖核酸(microRNAs,miRNAs)是一类普遍存在的长度约为18~25 nt的小分子RNA,通过与目标mR-NA分子的3′端非编码区域互补配对导致mRNA分子稳定性和翻译受到抑制,在调节细胞增殖、分化、凋亡和肿瘤发生等多种生物学过程中起重要作用。宫颈癌是一种潜在的可预防的疾病,仍然是女性最常见的第二大恶性肿瘤。越来越多的实验证据表明,一些microRNAs在宫颈癌中异常表达,microRNAs可作为癌基因或者抑癌基因,参与致癌过程,其中一些microRNAs在宫颈癌中发挥重要的作用。
MicroRNAs (miRNAs) are a ubiquitous small-molecule RNA of about 18-25 nt in length that results in mRNA molecular stability and translation by complementary pairing with the 3 ’non-coding region of the target mR-NA molecule Inhibition, play an important role in regulating a variety of biological processes such as cell proliferation, differentiation, apoptosis and tumorigenesis. Cervical cancer is a potentially preventable disease that remains the second most common malignancy in women. More and more experimental evidences show that some microRNAs are abnormally expressed in cervical cancer. MicroRNAs can be used as oncogenes or tumor suppressor genes and are involved in oncogenesis. Some of these microRNAs play an important role in cervical cancer.