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AIM To study the effect of 18-hydroxy-eicosapentaenoic acid(18-HEPE)and 17-hydroxy-docosahexaenoic acid(17-HDHA)in a murine model of obesity/nonalcoholic fatty liver disease.METHODS C57BL/6 mice were fed with standard chow diet(CD)or high-fat,fructose-enr