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吡哌酸为常用的抗菌药。中国药典1995年版已收载,但未规定有关物质的检查。日本药局方用薄层色谱法检查有关物质,试验中发现此方法展开后有拖尾现象。根据文献报道,经试验,筛选了下述薄层色谱条件,获得满意结果。 1 仪器与试剂 三用紫外线分析仪;硅胶HF_(254)(青岛海洋化工厂);甲醇、氯仿、甲苯及二乙胺等均为分析纯。 吡哌酸原料由山东新华制药厂提供。
Pipemidic acid is commonly used antibacterial drugs. Chinese Pharmacopoeia 1995 edition has been included, but did not provide for the inspection of substances. Japanese Pharmacopoeia thin layer chromatography to check the relevant substances, the test found that this method has a trailing phenomenon after deployment. According to reports in the literature, the following TLC conditions were selected to obtain satisfactory results. 1 instrument and reagent three ultraviolet analyzer; silica gel HF_ (254) (Qingdao Ocean Chemical Plant); methanol, chloroform, toluene and diethyl amine are all analytical grade. Pipemidic acid raw materials provided by Shandong Xinhua Pharmaceutical Factory.