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目的:探讨特异性免疫治疗(SIT)对鼻息肉伴常年性变应性鼻炎患者行功能性鼻窦内镜手术(FESS)的预后干预作用。方法:采用随机分组方法将确诊为鼻息肉伴常年性变应性鼻炎的患者随机分成2组,Ⅰ组:FESS+术后SIT组;Ⅱ组:FESS组。分别对2组患者进行术前、术后1年、术后2年症状及体征评分并进行对比,采用鼻腔鼻窦结局测量20条(SNOT-20),鼻内镜(Lund-Kennedy)评分法及CT(Lund-Mackay)评分法。结果:2组患者术后1年及2年SNOT-20量表的20个条目总分与5大条目总分、鼻内镜评分、CT评分指标均有明显好转(P<0.05),但2组间存在显著性差异,Ⅰ组疗效优与Ⅱ组。结论:SIT可减少鼻息肉术后复发,改善预后。
Objective: To investigate the effect of specific immunotherapy (SIT) on the prognosis of patients with nasal polyps and perennial allergic rhinitis undergoing endoscopic sinus surgery (FESS). Methods: Randomly divided patients with nasal polyps and perennial allergic rhinitis were randomly divided into two groups: group Ⅰ: FESS + postoperative SIT group; group Ⅱ: FESS group. The symptoms and signs of the two groups were evaluated preoperatively, 1 year after surgery and 2 years after surgery respectively. SNOT-20, Lund-Kennedy score, CT (Lund-Mackay) score method. Results: The scores of 20 items and 5 items of SNOT-20 in 1 year and 2 years postoperatively in both groups were significantly improved (P <0.05), but 2 There were significant differences between groups, Ⅰ group superior efficacy and Ⅱ group. Conclusion: SIT can reduce the recurrence of nasal polyps and improve the prognosis.