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1,3双[4′-(7′氯-喹啉基-4′)哌哔嗪-1]丙烷(简称:喹哌-Piperaquine)的碱或盐,对鼠疟均有长效抑制性预防作用,其作用的持续时间长短,随给药剂量增大而延长。喹哌碱每天50 mg/kg和200 mg/kg,连续灌胃3天,对鼠疟分别有15和60天预防作用;喹哌盐100 mg(碱基)/kg和300 mg(碱基)/kg一次灌胃,对鼠疟分别有30和45天预防作用。相同的给药剂量,喹哌盐的长效作用比喹哌碱好。喹哌碱、喹哌盐及磷酸氯喹,在相同给药剂量对比下,磷酸氯喹无长效预防作用。喹哌碱对鼠疟亦有良好治疗效果,从原虫血症转阴和治疗后的动物存活看,喹哌优于氯喹。
The base or salt of 1,3 bis [4 ’- (7’ chloro-quinolyl-4 ’) piperidine-1] propane (abbreviated name: piperaquine-dipiperazine) has long-term inhibitory prophylaxis against murine malaria Role, the duration of its role, with the dose increased and extended. Mequindox 50 mg / kg and 200 mg / kg daily for 3 consecutive days with 15 and 60 days protection against murine malaria, respectively; Quipiraxide 100 mg (base) / kg and 300 mg (base) / kg once gavage, respectively, 30 and 45 days of mouse malaria preventive effect. The same administration dose, the long-acting effect of quipiper salt is better than that of the mequindox. Quinalopentane, Quinalopil and Chloroquine Phosphatidylcholine showed no long-term preventive effect against chloroquine phosphate at the same dose. Quipramine also has good therapeutic effects on murine malaria. From the perspective of protozoospermia and post-treatment animal survival, quipo is superior to chloroquine.