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胃酸分泌受各种因素包括种族、性别、年龄等控制。在西方国家老年人胃酸分泌维持不降,而日本老人则由于萎缩性胃炎致使酸分泌下降。日本人由于幽门螺杆菌(Hp)感染率极高导致胃炎及胃粘膜萎缩发生率较高,因此随年龄增长的酸分泌下降是Hp感染的结果。近年来日本的Hp感染率在下降。本文调查了在过去20年中日本人群胃酸分泌是否有改变,若有则Hp感染起到什么影响?
Gastric acid secretion by a variety of factors, including race, gender, age and other control. In Western countries, gastric acid secretion in the elderly remains unchanged, while the Japanese elderly due to atrophic gastritis caused by decreased acid secretion. In Japan, due to the high infection rate of Helicobacter pylori (Hp) leading to a higher incidence of gastritis and gastric mucosal atrophy, the decrease of acid secretion with age is the result of Hp infection. In recent years, Japan’s Hp infection rate is declining. This article investigates whether gastric acid secretion has changed in the Japanese population in the past 20 years and if so what effect does Hp infection have?