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转化生长因子 β(TGF β)家族成员与各自的膜受体结合后 ,使通路限制性( pathway restricted)SMADs磷酸化 ,后者再与Smad4形成杂聚体并转位至细胞核 ,调节一些基因的转录而产生生物学效应。抑制性SMADs可阻断通路限制性SMADs的磷酸化。
Upon binding to the respective membrane receptor, members of the transforming growth factor β (TGFβ) family phosphorylate pathway restricted SMADs, which in turn form heteromeric aggregates with Smad4 and translocate to the nucleus, modulating the expression of some genes Transcription and produce biological effects. Inhibitory SMADs block the phosphorylation of pathway-restricted SMADs.