探讨米索前列醇(前列腺素E_1类似物)对骨缺失的恢复作用。研究开始,用盐酸氯胺酮(50mg/kg)麻醉30只sprague-Dawley大鼠,其中24只做卵巢切除手术(OVX),其余不切除卵巢(假手术组)。60天后,大鼠被分成4组,第1组给予溶媒,口服蒸馏水1ml/d,共60d,作为对照;第2、3组各6只分别给予100、200μg/kg/d米索前列醇60d。第4组(治疗前组)在卵巢切除60天后即处死,并测量其骨质状况。 To explore the recovery effect of misoprostol (prostaglandin E 1 analogue) on bone loss. Thirty Sprague-Dawley rats were anesthetized with ketamine hydrochloride (50 mg / kg), 24 of whom underwent ovariectomy (OVX) and the remaining without ovariectomy (sham). Sixty days later, the rats were divided into 4 groups. Group 1 was given vehicle and distilled water 1ml / d orally for 60 days as a control. Groups 6 and 6 were given 100,200μg / kg / d misoprostol for 60 days . Group 4 (pre-treatment group) was sacrificed 60 days after ovariectomy and the bone condition was measured.