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目的 研究黑质致密部 (SNc)神经元的放电型式与其对去甲肾上腺素 (NE)敏感性的关系 ,探讨“非周期敏感”现象的普遍性 .方法 在幼鼠的脑片胞外记录 SNc神经元的自发放电 .比较周期与非周期放电神经元对 NE反应的敏感性 ,对非周期放电神经元的放电进行非线性动力学分析 .结果 NE对 18个周期及 12个非周期放电神经元呈现兴奋作用 ,对 16个周期及 12个非周期放电神经元呈现抑制作用 .无论兴奋或抑制作用 ,非周期放电神经元对不同浓度 NE的反应程度均比周期放电神经元大 (P<0 .0 1) ;NE的兴奋及抑制作用可分别被酚妥拉明 (2 0μmol· L- 1 )及舒必利 (1μmol· L- 1 )阻断 ;在非周期放电神经元的放电序列中测出非稳定周期轨道 .结论 SNc的非周期放电神经元比周期放电神经元对 NE更敏感 ,这种敏感性可能与非周期放电的混沌特性有关 .
Objective To study the relationship between the discharge patterns of substantia nigra pars compacta (SNc) neurons and their sensitivity to norepinephrine (NE) and explore the prevalence of “aperiodic sensitivity” .Methods The extracellular recording of SNc Neurons spontaneous discharge.Compared the sensitivity of periodic and non-periodic discharge neurons to the NE response, the non-periodic discharge neurons were subjected to a non-linear kinetic analysis.Results Eighteen cycles and 12 non-periodic discharge neurons (P <0.05) .At the same time, the neurons in 16 cycles and 12 non-periodic discharges showed an inhibitory effect on the firing of neurons in the presence or absence of excitatory or inhibitory effects. 0 1). The excitatory and inhibitory effects of NE were blocked by phentolamine (20 μmol·L -1) and sulpiride (1 μmol·L -1), respectively. The firing rate of non-periodic discharge neurons Stable periodic orbit.ConclusionNonocyclic discharge neurons of SNc are more sensitive to NE than periodic discharge neurons.These sensitivities may be related to the chaotic characteristics of non-periodic discharge.