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转化生长因子β（ＴＧＦ－β）是一种多功能调节肽，对肠上皮细胞的增殖、发育、转化和分化都有一定的调节作用。ＴＧＦ－β抗增殖的一个重要机制是能抵抗其它肽类生长因子的促有丝分裂作用。它通过提高α２－整合素和癌胚抗原的表达、将细胞进程阻止在Ｇ１期诱导分化开始，而促进肠上皮分化。ＴＧＦ－β与细胞外基质有密切关系。结肠细胞失去对ＴＧＦ－β的反应有助于结肠癌的发生。
Transforming growth factor β (TGF-β) is a multifunctional regulatory peptide that regulates the proliferation, development, transformation and differentiation of intestinal epithelial cells. An important mechanism of antiproliferation of TGF-β is to mitigate the mitogenic effects of other peptide growth factors. It promotes intestinal epithelial differentiation by increasing the expression of [alpha] 2-integrin and carcinoembryonic antigen, preventing the cellular processes from initiating differentiation initiation in G1 phase. TGF-β and the extracellular matrix are closely related. Colon cell loss of TGF-β response contribute to the development of colon cancer.