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本文报告10名健康,生育期妇女,口服左旋18甲基炔诺酮作为事后药,每个月经周期用药0.75mg×5次。于用药前,用药一与三周期后及停药后一周期,分别测定空腹血清甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白-胆固醇(HDL-C)、载脂蛋白A_Ⅰ、A_Ⅱ、B(apoA_Ⅰ、apoA_Ⅱ、apoB)水平。结果显示TG、HDL-C水平及apoA_Ⅰ/A_Ⅱ比率均显著降低,P<0.05～P<0.01,而预测心血管疾病较可靠的指标(HDL-C/TC比率,apoA_Ⅰ/B比率)则未见有显著改变,即使apoA_Ⅰ/A_Ⅱ比率在用药第三周期有显著降低,P<0.01,停药后一周期即见恢复。从而说明,由于机体的调节功能,可使已改变的脂质水平能很快地达到平衡状态。本研究提示,短期服用18-甲对脂代谢的影响是轻微的。
This article reports 10 healthy women of reproductive age, oral levonorgestrel 18 as a post-natal drug, each menstrual cycle medication 0.75mg × 5 times. Fasting serum triglyceride (TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), apolipoprotein A_Ⅰ , A_Ⅱ, B (apoA_Ⅰ, apoA_Ⅱ, apoB). The results showed that the levels of TG, HDL-C and the ratio of apoA_Ⅰ / A_Ⅱwere significantly decreased, P <0.05 ~ P <0.01, but the more reliable indicators of cardiovascular disease (HDL-C / TC ratio, apoA_Ⅰ / B ratio) There was a significant change, even if the apoA_Ⅰ / A_Ⅱ ratio was significantly reduced in the third cycle of medication, P <0.01, that is recovered after a cycle of withdrawal. Thus, due to the body’s regulatory function, the altered lipid level can quickly reach equilibrium. This study suggests that the short-term use of 18-A lipid metabolism is minor.