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本文分析12例早期胃癌之病理资料,着重讨论了胃癌的组织发生。各种组织学类型的胃癌,无论粘膜上皮有或无肠化生,其癌变方式相同。癌变呈多中心与多时相性,均起始于胃小凹深部或腺颈部,少数亦可起始于深部腺体。癌变腺管作不规则分枝形成管状或乳头状腺癌,亦可向外作发芽状生长而呈低分化腺癌或未分化型癌,分化型癌继续生长多隆起于粘膜表面而突入胃腔,未分化型癌因向表面生长受限而常向侧方或胃壁深层浸润呈弥漫型癌。
This article analyzes the pathological data of 12 cases of early gastric cancer, focusing on the organization of gastric cancer. All kinds of histological types of gastric cancer, regardless of mucosal epithelium with or without intestinal metaplasia, have the same cancerous pattern. Carcinogenesis is multi-centered and multi-phase, both starting from deep gastric pit or gland neck, a few can also start in the deep glands. The cancerous glands are irregularly branched to form tubular or papillary adenocarcinomas. They can also grow outwardly as germinal growths and show poorly differentiated adenocarcinoma or undifferentiated carcinoma. The differentiated carcinoma continues to grow and bulges on the mucosal surface and protrudes into the stomach cavity. Undifferentiated carcinomas are often diffuse to the lateral or deep gastric wall due to the limited surface growth.