论文部分内容阅读
本文报道人参茎叶总皂甙(GSL)对58例急性非淋巴细胞白血病(急非淋白血病)细胞诱导分化作用的研究结果。其中原粒细胞白血病M_19例,M_215例,早幼粒细胞白血病M-312例,粒单细胞白血病M_414例,单核细胞白血病M_58例。结果表明:GSL对各型原代培养的急非淋白血病细胞均有不同程度的诱导分化作用,对急性粒单及单核细胞白血病细胞的诱导分化作用较强。除8例外,50例诱导后的细胞均表现出程度不同的形态学、功能及细胞化学方面的改变。这一研究结果提示,GSL可能成为治疗急性白血病的有效分化诱导剂。
This paper reports the results of the study on the differentiation of 58 cases of acute non-lymphocytic leukemia (emergency non-lymphocytic leukemia) cells by Ginseng stem and leaf saponins (GSL). There were M_19 myeloblastic leukemia patients, M_215 patients, M-312 promyelocytic leukemias, M_414 myelomonocytic leukemias, and M_58 myelomonocytic leukemias. The results showed that: GSL has different degrees of induction and differentiation effects on all types of primary cultured acute non-lymphocytic leukemia cells, and has a stronger effect on the differentiation and induction of acute granulocyte and monocyte leukemia cells. With the exception of 8 exceptions, 50 induced cells all showed varying degrees of morphological, functional, and cytochemical changes. This study suggests that GSL may be an effective inducer of differentiation in the treatment of acute leukemia.