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Purpose: To evaluate the cerebral blood flowvelocity in patients with ocular h ypertension. Material and methods: Twentyfour ocular hypertensive patients and 2 4 age-and sex-matched healthy volunteers were recruited in a prospective compa rative study. All subjects had normal findings on full-threshold visual field t ests and clinically normal optic nerves. All patients with ocular hypertension h ad an intraocular pressure (IOP) of > 21 mmHg on three separate occasions withou t treatment. Systolic and diastolic blood pressure by cuff,heart rate by palpati on,IOP by Goldmann applanation tonometry, central corneal thickness by ultrasoun d pachymetry, blood flow velocities, and pulsatility index of the ipsilateralmid dle cerebral artery by transcranial color Doppler were measured. Results: Systol ic and diastolic blood pressures (P=0.40 and P=0.45, respectively), heart rate ( P=0.30), and central corneal thickness (P=0.23) were similar in each group. Peak and end-diastolic blood flow velocities in the middle cerebral artery did not differ between ocular hypertensives and controls (P=0.37 and P=0.87, respectivel y). In addition, pulsatility index did not significantly differ between ocular h ypertensives and controls (P=0.61). Conclusions: The results of this study sugge st that ocular hypertension is not associated with reduction in blood flow veloc ity and elevation of resistance in the middle cerebral artery.
Objective: To evaluate the cerebral blood flow velocity in patients with ocular h ypertension. Material and methods: Twentyfour ocular hypertensive patients and 2 4 age-and sex-matched healthy volunteers were recruited in a prospective compa rative study. All subjects had normal findings on full All patients with ocular hypertension h ad an intraocular pressure (IOP) of> 21 mmHg on three separate occasions with treatment. Systolic and diastolic blood pressure by cuff, heart rate by palpati on , IOP by Goldmann applanation tonometry, central corneal thickness by ultrasoun d pachymetry, blood flow velocities, and pulsatility index of the ipsilateralmid dle cerebral artery by transcranial color Doppler were measured. Results: Systolic and diastolic blood pressures (P = 0.40 and P = 0.45, respectively), heart rate (P = 0.30), and central corneal thickness (P = 0.23) were similar in each group. Peak and end-diastolic blood flow velo In addition, the pulsatility index did not significantly differ between ocular hypertrophys and controls (P = 0.61). Conclusions: In addition, the pulsatility index did not differ differ between ocular hypertensives and controls (P = 0.37 and P = 0.87, The results of this study sugge st that ocular hypertension is not associated with reduction in blood flow veloc ity and elevation of resistance in the middle cerebral artery.