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目的比较硝苯地平与常用解痉镇痛药缓解肾、输尿管绞痛的疗效及副作用。方法顺序随机分组观察比较硝苯地平、阿托品、维生素 K3和阿托品加度冷丁缓解肾、输尿管绞痛的疗效及副作用。结果硝苯地平组的显效率和总有效率与阿托品加度冷丁组无显著性差异 ,但均显著高于阿托品组和维生素 K3组 (P<0 .0 5 ,P<0 .0 1) ;所有病例均未见严重副作用。硝苯地平组出现嗜睡、头晕、口干等症状均低于其他组。结论硝苯地平确有较强的解除肾、输尿管绞痛的作用 ,且见效快、安全、副作用少
Objective To compare the efficacy and side effects of nifedipine and commonly used antispasmodic analgesics in relieving renal and ureteral colic. Methods Randomized controlled trials were conducted to compare the efficacy and side effects of nifedipine, atropine, vitamin K3 and atropine plus chilled pethidine in relieving renal and ureteral colic. Results The effective rate and total effective rate of nifedipine group were not significantly different from that of atropine and chillemte but were significantly higher than that of atropine and vitamin K3 group (P <0.05, P <0.01). No serious side effects were observed in all cases. Nifedipine group appeared lethargy, dizziness, dry mouth and other symptoms were lower than other groups. Conclusion Nifedipine does have a strong effect of relieving renal and ureteral colic, and it is effective, safe, and has few side effects