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幽门螺旋菌(HP)引起以胃窦为主的慢性活动性胃炎,使易于发生粘膜萎缩及肠化,最终可导致胃癌。目前已知低酸分泌患者萎缩性胃炎迅速发生,为此作者研究抑酸治疗前后胃窦与胃体组织学变化,以阐明幽门螺旋菌相关胃炎变化。经内镜证实的十二指肠球部溃疡20例,良性胃溃疡6例,返流性食管炎21例和糜烂性胃炎3例。年龄20至79岁。在内镜检查前一月内未用抑酸、抗菌和铋剂治疗,且无严重基础疾病。所有病例给予奥美拉唑40mg/d连用8周。治疗前后经内镜在距幽门口2cm内取胃窦粘膜3块和距门齿50cm胃体大小弯侧粘膜6块,分别作HP培养和病理组织学检查。
Helicobacter pylori (HP) causes gastric anastomosis of chronic active gastritis, making it prone to mucosal atrophy and intestinal metaplasia, eventually leading to gastric cancer. It is known that atrophic gastritis occurs rapidly in patients with hypoacidosis. Therefore, the author studied histological changes of gastric antrum and gastric body before and after acid suppression therapy to clarify the changes of Helicobacter pylori-associated gastritis. 20 cases of duodenal ulcer confirmed by endoscopy, 6 cases of benign gastric ulcer, 21 cases of reflux esophagitis and 3 cases of erosive gastritis. Age 20 to 79 years old. No acid suppression, antibacterial and bismuth treatment within one month prior to endoscopy, and no serious underlying disease. All cases were given omeprazole 40mg / d for 8 weeks. Before and after treatment by endoscopy within 2cm from the pylorus to take antral mucosa 3 and 50cm away from the incisor incisors mucosa 6, respectively, for HP culture and histopathological examination.