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目的探讨大肠癌患者血清IL-8和MM P-3表达水平及其临床意义。方法应用EL ISA方法,对56例大肠癌患者和同期30名健康人的血清IL-8和MM P-3水平进行测定。结果大肠癌患者血清IL-8和MM P-3水平明显高于正常人,IL-8和MM P-3水平与肿瘤大小、血管侵犯、淋巴结受累、肝脏转移及临床病理分期密切相关(P<0.05),但与肿瘤部位、组织学类型及患者的性别和年龄等因素无关(P>0.05)。大肠癌患者血清IL-8和MM P-3水平表达有显著相关性(P<0.05)。结论IL-8和MM P-3在大肠癌的发生、发展中具有重要作用,术前检测IL-8和MM P-3可作为大肠癌辅助诊断和病情监测的参考指标。
Objective To investigate the expression of IL-8 and MM P-3 in patients with colorectal cancer and its clinical significance. Methods The serum levels of IL-8 and MM P-3 in 56 patients with colorectal cancer and 30 healthy people at the same period were measured by ELISA. Results The levels of IL-8 and MM P-3 in patients with colorectal cancer were significantly higher than those in normal people. The levels of IL-8 and MM-P-3 were closely related to tumor size, vascular invasion, lymph node involvement, liver metastasis and clinicopathological stage (P < 0.05), but not with tumor location, histological type and gender and age of the patients (P> 0.05). The expression of IL-8 and MM P-3 in colorectal cancer patients was significantly correlated (P <0.05). Conclusion IL-8 and MM P-3 play an important role in the carcinogenesis and progression of colorectal cancer. Preoperative detection of IL-8 and MM-P-3 can be used as a reference for the diagnosis and monitoring of colorectal cancer.