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目的探讨不同剂量131Ⅰ对青年甲状腺功能亢进症的疗效影响。方法选择青年弥漫性甲状腺肿伴甲状腺功能亢进症患者54例,依据给药剂量分为小剂量组和常规剂量组,比较两组131Ⅰ治疗后的近期疗效。结果小剂量组与常规剂量组治愈率比较差异无统计学意义(81.5%vs 88.9%,P>0.05),甲状腺功能减低率两组比较差异有统计学意义(3.7%vs 11.1%,P<0.05),1年后的甲状腺功能亢进症复发率两组比较差异无统计学意义(11.1%vs 7.4%,P>0.05),两组均无严重不良反应发生。结论小剂量131Ⅰ治疗青年甲状腺功能亢进症疗效良好,可降低早发性甲状腺功能低下的发生率。
Objective To investigate the effect of different doses of 131 Ⅰ on young hyperthyroidism. Methods 54 cases of diffuse goiter with hyperthyroidism in young patients were divided into low dose group and conventional dose group according to the dose, and the short-term curative effect after 131 Ⅰ treatment was compared between the two groups. Results There was no significant difference in the cure rate between the low dose group and the conventional dose group (81.5% vs 88.9%, P> 0.05). The rate of hypothyroidism was significantly different between the two groups (3.7% vs 11.1%, P <0.05 ). The recurrence rate of hyperthyroidism after one year showed no significant difference between the two groups (11.1% vs 7.4%, P> 0.05). No serious adverse reactions occurred in both groups. Conclusion Low dose 131 Ⅰ treatment of hyperthyroidism in young patients with good effect, can reduce the incidence of early hypothyroidism.