论文部分内容阅读
目的探讨手术联合药物治疗中重度子宫内膜异位症的临床疗效。方法选择2005年1月至2009年10月我院收治确诊为Ⅲ～Ⅳ期子宫内膜异位症的患者共90例,将其随机平均分为两组,1组45例,为术后加用孕三烯酮,2组45例,为术后加用诺雷德治疗。两组疗程均为6个月。所有患者均随访2年,比较两组患者术后疗效、复发率、妊娠率及药物副作用。结果诺雷德组术后疗效、复发率、妊娠率均优于孕三烯酮组,差异均有统计学意义(P<0.05)。孕三烯酮组药物副反应以肝功能影响及高雄激素症状为主,停药1～6个月恢复;诺雷德组表现为低雌激素所致的更年期症状,于停药后1～2个月恢复,低雌激素以反向添加疗法预防。结论手术后联合诺雷德治疗中重度子宫内膜异位症的疗效比联合孕三烯酮好,值得临床推广应用。
Objective To investigate the clinical efficacy of surgery combined with drugs in the treatment of moderate and severe endometriosis. Methods A total of 90 patients with endometriosis diagnosed as stage Ⅲ-Ⅳ were selected from January 2005 to October 2009 in our hospital. They were randomly divided into two groups, 45 cases in one group, With gestrinone, two groups of 45 cases, for the postoperative use of Nuodeidi treatment. Two courses of treatment are 6 months. All patients were followed up for 2 years. The curative effect, recurrence rate, pregnancy rate and drug side effects were compared between the two groups. Results The efficacy, recurrence rate and pregnancy rate of the Noreideide group were better than those of the Gestrinone group (P <0.05). Gestrinone group side effects of drugs to liver function and symptoms of hyperandrogenism, withdrawal 1 to 6 months recovery; Noridex group showed low estrogen-induced menopause symptoms in the withdrawal of 1 to 2 Month recovery, low estrogen to reverse therapy to prevent. Conclusion The combined operation of Noreid after surgery is more effective than gestrinone in the treatment of moderate-severe endometriosis, which is worthy of clinical application.