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目的:探讨听觉事件相关电位(ERP)在癫癎患者中的应用价值。方法:对40例癫癎患者和30名正常人进行ERP检测比较,并将癫癎患者ERP的结果与其发作类型、用药情况等进行比较分析。结果:40例癫癎患者的ERP P300潜伏期较对照组延长(P<0．05),但其P300波幅差异无统计学意义(P>0．05)。全身强直阵挛性发作的28例癫癎患者,P300潜伏期延长尤著。多药治疗组较单药治疗组P300潜伏期延长。结论:癫癎患者存在认识功能障碍,ERP可作为癫癎患者认知功能障碍诊断的参考指标,对指导临床,及早给予干预和治疗有一定意义。
Objective: To investigate the value of auditory event-related potential (ERP) in patients with epilepsy. Methods: 40 cases of epilepsy patients and 30 normal subjects were compared by ERP, and the results of epilepsy patients with ERP and the type of seizure, medication and other comparative analysis. Results: The latency of ERP P300 was prolonged in 40 epilepsy patients (P <0.05), but there was no significant difference in the amplitude of P300 among them (P> 0.05). 28 cases of epileptic seizures in patients with generalized tonic clonic seizures, P300 particularly prolonged latency. Multi-drug treatment group than monotherapy group P300 latency. Conclusion: There are cognitive dysfunction in epilepsy patients, and ERP can be used as a reference index in the diagnosis of cognitive impairment in epilepsy patients. It is of great significance to guide clinical and early intervention and treatment.