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目的:总结国产瑞替普酶联合磺达肝癸钠治疗急性ST段抬高性心肌梗死(STEMI)的临床疗效和安全性。方法:收集2011-03-2011-10我院年龄≤75岁的STEMI患者32例,给予国产瑞替普酶联合磺达肝癸钠治疗,观察临床效果。结果:90min临床判断血管再通24例(75.0%),5例(15.6%)患者接受介入治疗,全部患者住院期间无严重出血、过敏及死亡事件发生。结论:国产瑞替普酶联合磺达肝癸钠是STEMI患者再灌注治疗用药的理想组合。
Objective: To summarize the clinical efficacy and safety of domestic reteplase combined with fondaparinux in the treatment of acute ST-segment elevation myocardial infarction (STEMI). Methods: Thirty-two STEMI patients aged ≤75 years from 2011-03-2011-10 were enrolled in this study. The patients were treated with reteplase plus fondaparinux and the clinical effect was observed. Results: In 90 minutes, 24 cases (75.0%) were diagnosed as vascular recanalization and 5 cases (15.6%) were treated by interventional therapy. No serious bleeding, allergic reaction and death occurred during hospitalization. Conclusion: Domestic reteplase combined with fondaparinux is the ideal combination of STEMI reperfusion therapy.