幼淋细胞白血病(Prolymphocytic Leukaemia)(PLL)国内外均有数篇报导,是以脾巨大,常用治疗慢淋的药物疗效差,幼淋细胞占优势的淋巴细胞恶性增殖性疾患。对其超微结构的研究国外已有少数报导。我们对一例慢淋幼淋变病人骨髓中的幼淋细胞用TEM观察其超微结构并与光学显微镜下瑞氏染色涂片的形态进行了对比。病历摘要:刘×、女性、40岁,四年前因牙龈出血、乏力住某院,经骨穿活检诊断为:慢性淋巴细胞白血病(CLL)。按CLL治疗最初有效,但近来脾脏明显肿大,化疗无效,疑幼淋细胞白血病或慢淋幼淋变于1984年2月转入我院。体检:贫血貌,全身浅表淋巴结为黄豆至枣大,质硬无触痛,脾肋下23cm,质硬边钝,表面光滑无 Prolymphocytic leukemia (PLL) has several reports at home and abroad, is a large spleen, commonly used in the treatment of chronic drug poor efficacy, lymphocytic malignant proliferative disorders preponderant lymphocytes. There have been a few reports on its ultrastructure abroad. We observed the ultrastructure of the lymphocytes in a bone marrow of a patient with chronic lymphocytic leukemia by TEM and compared the morphology of the Wright smear smears under an optical microscope. Medical records summary: Liu ×, female, 40 years old, bleeding gums four years ago due to fatigue in a hospital, diagnosed by bone biopsy as chronic lymphocytic leukemia (CLL). According to CLL treatment initially effective, but recently the spleen was significantly enlarged, chemotherapy is invalid, suspected juvenile leukemia or chronic lymphocytic leukemia in February 1984 transferred to our hospital. Physical examination: anemia appearance, the body superficial lymph nodes to jujube large, hard no tenderness, spleen ribs 23cm, blunt hard edge, smooth surface