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p53作为广泛存在的肿瘤抑制基因 ,最近发现了其家族成员 :p73和p63。它们在结构和功能上具有相似性 ,均能触发细胞周期停滞 ,诱导凋亡 ,但它们在肿瘤抑制和组织发育中起着截然不同的作用 ,深入了解它们彼此之间的相似性和差异将对理解肿瘤发生的机制产生重要的影响。本文总结了最近几年来此领域内的最新进展。另外 ,p73和p63在C端的SAM结构说明它们可能参与组织的发育过程。
As a widely existing tumor suppressor gene, p53 recently discovered its family members: p73 and p63. They are structurally and functionally similar and both trigger cell cycle arrest and induce apoptosis, but they play a distinctly different role in tumor suppression and tissue development. An in-depth understanding of their similarities and differences with each other will Understanding the mechanisms of tumorigenesis has important implications. This article summarizes the latest developments in this area in recent years. In addition, the SAM structures of p73 and p63 at the C-term indicate that they may be involved in the development of the tissue.