论文部分内容阅读
目的:探讨双补九味汤对小儿反复呼吸道感染的临床疗效及免疫调节的影响。方法:将77例反复呼吸道感染(RRTI)患儿随机分为观察组和对照组。观察组给予中药自拟双补九味汤每日1剂,水煎分2次口服。对照组给转移因子口服液,每次10 mL,每天2次口服。2组疗程均为2个月。2组治疗前后检测血IgA,IgG,IgM,IL-12,TNF-α,INF-γ水平,评价2组临床疗效及免疫因子的变化,同时设健康组。结果:2组血清IgA,IgG,IgM,IgE,IL-12,TNF-α,INF-γ水平治疗前与健康组比差异有显著性(P<0.01)。治疗后2组IgA,IgG,IgM,IL-12,TNF-α,INF-γ水平比差异有显著性(P<0.01);2组患儿复发次数与临床疗效比较,观察组明显优于对照组,差异有显著性(P<0.01)。结论:双补九味汤对小儿反复呼吸道感染的临床疗效及免疫调节均有显著影响。
Objective: To investigate the Shuangbujiwei soup on children with recurrent respiratory tract infection and clinical efficacy of immunomodulatory effects. Methods: 77 children with recurrent respiratory tract infection (RRTI) were randomly divided into observation group and control group. Observation group given Chinese medicine Shuangbu nine soup one day, decoction 2 times orally. Control group to transfer factor oral solution, each 10 mL, 2 times a day orally. 2 groups of treatment are 2 months. The levels of IgA, IgG, IgM, IL-12, TNF-α and INF-γ in the two groups before and after treatment were measured. The clinical efficacy and immune factors in the two groups were also evaluated. Results: The levels of serum IgA, IgG, IgM, IgE, IL-12, TNF-α and INF-γ in the two groups before treatment were significantly different from those in healthy group (P <0.01). There were significant differences in the levels of IgA, IgG, IgM, IL-12, TNF-α and INF-γ between the two groups after treatment (P <0.01). The recurrence frequency and clinical efficacy of the two groups were significantly better than the control group Group, the difference was significant (P <0.01). Conclusion: Shuangbujiwei decoction has significant effect on the clinical efficacy and immune regulation of recurrent respiratory tract infections in children.