论文部分内容阅读
自从维甲酸（ＲＡ）被用于诱导分化治疗恶性肿瘤，特别是被用于治疗急性早幼粒细胞白血病（ＡＰＬ）以来，人们对其进行了广泛的研究．一方面对其分子结构进行改造，以寻找高效低毒的维甲类抗肿瘤药物．另一方面对其抗肿瘤机制进行深入研究．维甲类药物抗肿瘤机制包括抑制增殖、诱导分化、促进凋亡、增加免疫等多个方面，它在体内的作用是通过一系列信号传递系统实现的．对最近十多年来维甲类抗肿瘤药物的研究状况作了扼要的综述
Since retinoic acid (RA) has been used to induce differentiation in the treatment of malignancies, in particular since it has been used to treat acute promyelocytic leukemia (APL), it has been extensively studied. On the one hand, the molecular structure of its transformation, in order to find efficient and low toxicity of retinoid anti-tumor drugs. On the other hand its anti-tumor mechanism in-depth study. The anti-tumor mechanisms of retinoids include inhibiting proliferation, inducing differentiation, promoting apoptosis and increasing immunity, and its role in the body is achieved through a series of signaling systems. This review summarizes the research status of the retinoid antitumor drugs in recent ten years