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测定了32名健康老年人和13名健康青年人周围血淋巴细胞糖皮质激素受体(GCR)和血浆皮质醇浓度,同时测定了18只老年大鼠和9只青年大鼠的脾淋巴细胞 GCR,并用补肾益气中药观察其对 GCR 老年性改变的影响。结果表明,GCR 较血皮质醇能更敏感地反映肾上腺皮质功能,老年人及老年鼠的 GCR 均较青年组明显降低,而血皮质醇则无增龄性变化。补肾益气中药能提高老年人及老年大鼠低下的 GCR 水平,藉以改善肾上腺皮质功能。
The concentration of glucocorticoid receptor (GCR) and plasma cortisol in peripheral blood lymphocytes of 32 healthy elderly and 13 healthy young people were measured. GCR of spleen lymphocytes in 18 aged rats and 9 young rats was also measured. , And observe the effect of Bushenyiqi medicine on its aging changes in GCR. The results showed that GCR can reflect adrenocortical function more sensitively than blood cortisol. The GCR of elderly and aged rats was significantly lower than that of the younger group, whereas there was no age-related change in blood cortisol. Bushenyiqi herbs can improve the low GCR levels in elderly and older rats to improve adrenocortical function.