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目前,在一些基层医院仍有医生喜欢用见效快的退烧针(如复方氨基比林和安乃进)治疗儿童急性发热,这种做法对儿童身体危害极大。以往的研究证实,退烧针的降温作用机制是抑制人体下丘脑中前列腺素合成酶,致中枢内前列腺素合成和释放减少,阻断内热原使体温调定点下移,通过增加散热使皮肤血管扩张、血流量增加、出汗增多而降低体温。就以复方氨基比林来说,该药组方中氨基比林可引起白细胞抗原结构的改变导致外周血中白细胞减少,其发生率远高于氯霉素。
At present, there are still some physicians in some grass-root hospitals who prefer to treat feverish children with feverish fever needles (such as compound aminopyrine and amphetamines). This is a great harm to children’s bodies. Previous studies confirmed that the mechanism of antipyretic needle cooling is to inhibit the human hypothalamic prostaglandin synthase, central synthesis and release of prostaglandin reduced, blocking the endogenous pyrogen to the body temperature set point down, by increasing the skin heat expansion of blood vessels , Increased blood flow, increased sweating and lower body temperature. As for the compound aminopyrine, the aminopyrine in the prescription of the drug group can cause the leukocyte reduction in the peripheral blood caused by the change of the leukocyte antigen structure, and its incidence is much higher than that of chloramphenicol.