论文部分内容阅读
法国巴黎消息:一类新的广谱抗生素引起了人们的注意。虽然此药在美国还未应用,但研究人员警告说,此药不可滥用。在此召开的拜耳药厂药学专家讨论会上,研究人员指出,Quinolone衍生物应用非常广泛。由于应用广泛,反而有损于它的最大的优点,即对抗各种多样抗药菌株的效用。独特的作用 Quinolone在抗菌作用方面具有独特的作用机制。它阻断细菌的DNA促旋酶,此酶对较大的细菌染色体的复制及超螺旋化(Supercoiling)是不可少的;而细菌染色体的超螺旋化使DNA促旋酶(gyrase)适于较小的细胞壁。伦敦大学的微生物学家John Thomas指出,这一作用使Quinolone不易受质粒所产生的抗药性的破坏。
Paris, France: A new class of broad-spectrum antibiotics has caught the eye. Although the drug has not been applied in the United States, the researchers warn that the drug should not be abused. At this Bayer pharmaceutical pharmaceutical experts workshop, researchers pointed out that Quinolone derivatives are widely used. Due to its wide range of applications, however, it is detrimental to its biggest advantage, that is, against a variety of drug-resistant strains of utility. Unique Role Quinolone has a unique mechanism of action in terms of antibacterial effects. It blocks bacterial DNA gyrase, which is essential for the replication and supercoiling of larger bacterial chromosomes; the supercoiling of bacterial chromosomes makes DNA gyrase suitable Small cell wall. John Thomas, a microbiologist at the University of London, said that this effect makes Quinolone less susceptible to plasmid-induced drug resistance.