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目的 :观察己酮可可碱注射液对肺纤维化的影响。方法 :采用气管内灌注博莱霉素的方法复制大鼠肺纤维化模型 ,同时设正常对照组、己酮可可碱治疗组 ,取肺进行HE染色、Masson染色和羟脯氨酸含量测定。结果 :纤维化模型组发生肺纤维化 ,己酮可可碱治疗组未发生明显的肺纤维化 ,其指标与正常组无差异。结论 :己酮可可碱注射液有抗大鼠肺纤维化的作用。
Objective: To observe the effect of pentoxifylline injection on pulmonary fibrosis. Methods: The rat model of pulmonary fibrosis was established by intratracheal instillation of bleomycin. At the same time, the normal control group and pentoxifylline treatment group were taken. The lungs were taken for HE staining, Masson staining and hydroxyproline content determination. Results: Pulmonary fibrosis occurred in the fibrosis model group. No significant pulmonary fibrosis occurred in the pentoxifylline treatment group. There was no significant difference between the two groups in the index and the normal group. Conclusion: Pentoxifylline injection can prevent pulmonary fibrosis in rats.