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[目的]探讨双环醇治疗乙醇性肝病的临床效果。[方法]64例酒精性性肝病患者随机分为两组,对照组32例,仅给予戒酒、低脂肪、富营养饮食及口服肌苷片常规治疗,观察组32例,在上述基础上加用双环醇片(25～50mg,3次/d)口服;两组均连续用药8周,均未使用降酶药物。治疗前后进行肝功能的多项指标(ALT、AST、GGT、Alb、TBil)检查,评定肝功能变化。[结果]观察组总有效率96.4%,对照组78.3%,两组比较差异有统计学意义,P﹤0.05。观察组治疗后,患者肝功能指标ALT、AST、GGT、TBil明显降低、Alb增加,治疗前后比较差异均有统计学意义(分别P﹤0.01,P﹤0.05)。双环醇治疗期间未见不良反应。[结论]双环醇治疗酒精性性肝病效果好,不良反应少,临床值得推广。
[Objective] To investigate the clinical effect of bicyclol in the treatment of alcoholic liver disease. [Method] Sixty-four patients with alcoholic liver disease were randomly divided into two groups. The control group was given only alcohol, low fat, eutrophic diet and oral inosine tablets routinely. The observation group consisted of 32 cases. On the basis of the above, With bicyclic alcohol tablets (25 ~ 50mg, 3 times / d) orally; two groups were administered for 8 weeks, did not use Jiangdu drugs. Before and after treatment for a number of indicators of liver function (ALT, AST, GGT, Alb, TBil) examination, assessment of liver function changes. [Results] The total effective rate was 96.4% in the observation group and 78.3% in the control group, the difference between the two groups was statistically significant (P <0.05). After treatment, the ALT, AST, GGT, TBil, Alb in the observation group were significantly increased (P <0.01, P <0.05, respectively). No adverse reactions were observed during treatment with bicyclol. [Conclusion] Bicyclol is effective in treatment of alcoholic liver disease with less adverse reactions and is worth clinical promotion.