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生长激素抑制素(SST)是一种参与内分泌系统调节、神经传递和细胞增殖的多肽类激素。SST通过5个特征明显而不同的G蛋白偶联受体传递信号。假设每个受体的特征都不同,通用SST受体调质选择性的不足会限制该受体家族治疗潜力的开发。Martin等用一种巧妙的化学方法已设计出第1个SST?
Somatostatin (SST) is a polypeptide hormone involved in endocrine system regulation, neurotransmission and cell proliferation. SSTs transmit signals through five distinct and distinct G protein-coupled receptors. Assuming that each receptor has different characteristics, the lack of selectivity for the universal SST receptor limits the development of the therapeutic potential of this receptor family. Martin et al. Have designed the first SST in a clever chemistry?