目的探讨甲胎蛋白(AFP)、糖类抗原199(CA199)、β2-微球蛋白(β2-MG)联合检测对原发性肝癌的诊断价值。方法采用电化学发光法检测AFP、CA199的水平,采用免疫比浊法测定β2-MG。结果原发性肝癌患者血清AFP、CA199、β2-MG测定值明显高于慢性肝病及健康对照组。结论联合检测有助于提高原发性肝癌的早期诊断率。 Objective To investigate the diagnostic value of AFP, CA199 and β2-MG in the diagnosis of primary liver cancer. Methods The levels of AFP and CA199 were detected by electrochemiluminescence. Β2-MG was measured by immunoturbidimetry. Results The serum AFP, CA199 and β2-MG levels in patients with primary liver cancer were significantly higher than those in patients with chronic liver disease and healthy controls. Conclusion Combined detection can help improve the early diagnosis of primary liver cancer.