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目的:以缺铁大鼠为模型研究了云亭牌阿胶口服液改善营养性贫血的效果。方法:选择体重60~80 gⅡ级雌性断乳Wistar大鼠,给予低铁基础饲料耗空6周后,经尾静脉取血,测定血红蛋白含量,按尾血血红蛋白含量和体重,把动物随机分为低铁对照组和3个实验组。根据该样品的人体日推荐用量,实验组设2.5、5.0、10.0 ml/kg BW(分别相当于人体推荐用量的5、10、20倍)低、中、高3个剂量组;低铁对照组给予相应溶剂。实验期为45 d,测定动物营养性贫血相关指标。结果:云亭牌阿胶口服液改善大鼠生长,各剂量实验组的终体重和净增重高于低铁对照组;服用云亭牌阿胶口服液显著升高贫血大鼠的血红蛋白水平;而红细胞内游离原卟啉水平显著降低。结论:云亭牌阿胶口服液有改善营养性贫血的作用。
OBJECTIVE: To study the effect of Yunting Pai Ejiao Oral Liquid in improving nutritional anemia in iron deficiency rats. Methods: The Wistar rats, weighing 60 ~ 80 g, were divided into two groups according to the tail blood hemoglobin content and body weight Low-iron control group and three experimental groups. According to the human body recommended daily dosage of the sample, the experimental group was set at low, medium and high doses of 2.5, 5.0 and 10.0 ml / kg BW (corresponding to 5, 10 and 20 times the recommended doses of the human body respectively) Give the appropriate solvent. The experimental period was 45 days, and the index of animal nutritional anemia was determined. Results: Yutingping Ejiao oral liquid improved the growth of rats. The final body weight and net weight gain of each dose group were higher than that of the low iron control group. Taking Yunting Paijiao oral liquid significantly increased the hemoglobin level of anemia rats. Within the free protoporphyrin levels were significantly lower. Conclusion: Yuting Pavilion Ejiao oral liquid has the effect of improving nutritional anemia.